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For Dogs With Heart Murmurs, Here’s Some Important News

This drug, when given early, can potentially extend the lives of dogs with a particular type of heart murmur.

Dogs With Heart Murmurs
Starting the medicine pimobendan early in at-risk dogs with heart murmurs can pay off. Photo: Pixabay

Not so many years ago, a person with a happy, healthy dog with a loud heart murmur would be advised by their veterinarian to wait and start treatment only once signs of heart failure developed.

Here’s a general list of signs of heart failure in dogs:

  • A hacking cough
  • Increased breathing rate at rest
  • Labored breathing
  • Lack of energy
  • Inability to exercise
  • Collapse
  • Blue-tinged or pale gums

This wait-and-see approach to dogs with heart murmurs was accepted wisdom until a few years ago.

Back then, we all believed starting drugs too early, before the dog developed a cough or struggled to exercise, would reduce the medication’s effectiveness when the dog really needed it.

But this advice has changed.

Evidence-Based Medicine for Dogs With Heart Murmurs

Vets now know that a certain drug, when given early (before clinical signs develop), markedly extends the life expectancy of dogs with Grade 3 murmurs that are due to leaky heart valves.

Today’s veterinary world relies on evidence-based medicine.

This isn’t the sort of evidence where the vet once had a patient with X terminal disease and gave drug Y, and the dog made a full recovery. No, this isn’t about personal experience but instead repeatable scientific fact.

The evidence has to be solid and factual, with a statistical analysis that stands up to scrutiny and has irrefutable results. And the EPIC study into the treatment of heart murmurs has all of this.1,2

Medication for Dogs With Heart Murmurs: Pimobendan

The name of the drug in question is pimobendan (Vetmedin).

In truth, pimobendan has been around for years. In fact, your dog may already be on it. What’s different is the timing of when the drug is started.

Vets now have real, hard evidence that starting pimobendan early in at-risk dogs with heart murmurs has big benefits, such as:

  • A one-third reduction in the likelihood of developing heart failure at any given time (when compared with similar dogs not on any treatment)
  • 15 months more good-quality life than similar dogs not receiving pimobendan

Indeed, the benefits to dogs with wonky hearts were so marked that the clinical trial had to be halted ahead of time.

It became clear that the dogs in the control group (those not receiving a sugar pill) were becoming sick sooner and living less than those on pimobendan. On ethical grounds, it simply wasn’t fair to withhold a beneficial drug once the truth was recognized.

Dogs With Heart Murmurs
Signs of heart failure in a dog can include labored breathing and a lack of energy. Photo: WerbeFabrik

Pimobendan and Your Dog

OK, so during a physical exam, the veterinarian discovers your dog has a heart murmur. If your dog is fit and well, the dog should start pimobendan, right?


Unfortunately, things are more complicated than that.

This is where a bit of science comes in.

First, there’s a big difference between having a heart murmur versus heart failure:

  • Heart murmur: A murmur refers to the noise made when some blood leaks in the wrong direction through a heart valve.
    • Murmurs vary from mild (Grade 1) to severe (Grade 6).
    • Some murmurs stay the same for the duration of the dog’s life, some go away and others get worse with time.
    • For much more on murmurs, see our previous article on the subject.
  • Heart failure: This happens when the heart fails as a pump and can’t push enough blood around the body. Heart failure can be controlled (for a while) with drugs, but it can’t be cured.

The trick is to work out which group the dog belongs to.

Doing so requires a bit of wizardry with a cardiac ultrasound scan that looks for heart enlargement.

This is because there’s a sweet spot where the dog shows physical changes in the shape of the heart but they’re still fit and well. This is the dog who will benefit from taking pimobendan early.

Heart Scans

Right now, your heart might be sinking — you don’t want your dog to have more tests.

Don’t panic. Dogs with soft murmurs (Grades 1–2) can sit tight and wait some more. These dogs are exceedingly unlikely to have heart enlargement. Quite simply, their hearts are still very fit.

However, if a vet hears a Grade 3 murmur, they will sit up and take notice.

Heart Murmur Grades in Dogs

The vet listens with a stethoscope to the dog’s chest.

  • Grade 1: The softest murmur — so quiet it takes minutes of careful listening in a quiet room to detect it
  • Grade 2: A soft murmur heard without difficulty
  • Grade 3: Low to moderate noise
  • Grade 4: Moderate to loud noise
  • Grade 5: Loud noise that makes the chest wall vibrate
  • Grade 6: So loud that the murmur is heard with the stethoscope not directly against the chest wall

Grade 3 dogs are those most likely to be well but teetering on the edge of becoming sick. A heart scan allows the vet to take measurements of the heart’s size, which can catch the dog before heart failure starts.

So the dog with a quiet murmur should have a vet listen to their chest every 6–12 months to detect any changes. For dogs who are outwardly well but have a Grade 3 murmur, imaging will detect signs of wear and tear.

Then you can decide whether or not to start pimobendan, a drug that could reduce the risk of heart failure by around 33% and increase the dog’s life expectancy by 15 months.

This veterinarian explains the ins and outs of heart murmurs in dogs:

YouTube player

The Downside to Pimobendan for Dogs With Heart Murmurs

In truth, the major downside is cost.

Heart scans are expensive, and the drug itself isn’t cheap. Several years on an expensive heart med can total up to a tidy sum.

Finally, even with pimobendan, a few dogs will defy the odds and not do so well. Such is the law of averages and the pitfall of statistics.

But with pimobendan for dogs with heart murmurs, there is new hope.


  1. “EPIC Study: Evaluation of Pimobendan.” Royal Veterinary College, University of London. Oct. 4, 2016.
  2. “About the EPIC Study: Breaking New Ground in Canine Heart Health.” Boehringer Ingelheim Vetmedica GmbH.
vet-cross60pThis pet health content was written by a veterinarian, Dr. Pippa Elliott, BVMS, MRCVS. It was last reviewed Jan. 26, 2018.

If you have questions or concerns, call your vet, who is best equipped to ensure the health and well-being of your pet. This article is for informational purposes only and is not a substitute for professional medical advice, diagnosis or treatment. See additional information.